Author

Nicholas Denomme

Stanford MedicineORCID 0000-0002-7631-0385Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Gavin C. TouponseiD· 2 shared Matthew B. PomrenzeiD· 2 shared Neir EsheliD· 2 shared Robert C. MalenkaiD· 2 shared Zihui ZhangiD· 2 shared Allen P. F. CheniD· 1 shared Amei N. Shank· 1 shared Andreas R. PfenningiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Gavin C. TouponseORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion

Matthew B. Pomrenze, Jason Tucciarone, Gavin C. Touponse, Nicholas Denomme, BaDoi N. Phan, Robyn St. Laurent, Julia A Galiza Soares, Daniel F. Cardozo Pinto, Michaela Y. Guo, Jinhee Baek, Allen P. F. Chen, Zihui Zhang, Amei N. Shank, Zachary Freyberg, Andreas R. Pfenning, , Robert C. Malenka

The paper identifies Tshz1 neurons in the nucleus accumbens as critical for withdrawal aversion by modulating dopamine release and mGluR8 activity, offering a new therapeutic target for opioid use disorder.

bioRxiv · May 28, 2026 · PreprintNeuroscience

A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition

Elizabeth R. Park, Nicholas Denomme, Holly S. Hajare, J. Du Bois

This paper develops a chemogenetic tool to selectively inhibit specific voltage-gated sodium channel subtypes with high precision and reversibility.

bioRxiv · Nov 3, 2025 · PreprintNeuroscience

Interpretable Machine Learning Identifies an Emergent Absence Seizure Mechanism

Jacob M. Hull, Nicholas Denomme, Surya Ganguli, John R. Huguenard

The paper uses interpretable machine learning to derive dynamical equations from seizure data, revealing a chaotic attractor mechanism in thalamocortical circuits that drives absence seizures.

bioRxiv · Sep 23, 2025 · PreprintNeuroscience

Cholinergic modulation of dopamine release drives effortful behavior

Gavin C. Touponse, Matthew B. Pomrenze, Teema Yassine, Viraj Mehta, Nicholas Denomme, Zihui Zhang, Robert C. Malenka, Neir Eshel

The paper shows that cholinergic modulation of dopamine release enhances effortful behavior by amplifying dopamine responses to high-effort rewards.

bioRxiv · Jun 18, 2025 · PreprintNeuroscience