This study identifies a 79-nucleotide sequence from the Arabidopsis CYSTM1 5'UTR that significantly enhances transgene expression in plants and bacteria.

Genes · Apr 28, 2026Peer-reviewedPlant Biology

CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators

Liang Fang, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Yang Jiao, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, , Wei Chen

CIGAR-seq identifies mRNA modification regulators through CRISPR screening and RNA modification readout, revealing NSUN6 as a novel m5C methyltransferase.

Molecular Systems Biology · Nov 1, 2020Peer-reviewedMolecular Biology

Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth.

Qianqian Guo, Pei Qin Ng, Shanshan Shi, Diwen Fan, Jun Li, Jing Zhao, Hua Wang, Rakesh David, Parul Mittal, Trung Do, Ralph Bock, Ming Zhao, Wenbin Zhou, Iain Robert Searle

This study identifies AtTrm5 as a bifunctional tRNA methyltransferase in Arabidopsis, showing its role in tRNA modifications and plant growth.

PLoS ONE · Nov 22, 2019Peer-reviewedMolecular Biology

Gut Microbiota in male patients with chronic traumatic complete spinal cord injury

Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, , Jianjun Li

This study analyzes gut microbiota differences between healthy adults and chronic traumatic complete SCI patients, finding dysbiosis linked to serum biomarkers and neurogenic bowel dysfunction.

Journal of Translational Medicine · Dec 1, 2018Peer-reviewedNeuroscience