Author

Joachim Loup

University of TorontoORCID 0000-0002-0033-5033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

C. H. ArrowsmithiD· 2 shared Dalia Barsyte-LovejoyiD· 2 shared Madhushika SilvaiD· 2 shared Matthieu SchapiraiD· 2 shared Vijayaratnam SanthakumariD· 2 shared A. M. EdwardsiD· 1 shared Aiping DongiD· 1 shared Albina Bolotokova· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

C. H. ArrowsmithORCID

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2 papers

Recent·Most cited

Development of a dual chemical probe for the USP16 and HDAC6 zinc-finger ubiquitin-binding domain

Madhushika Silva, Mandeep Kaur Mann, Bijan Mirabi, Magdalena M. Szewczyk, Joachim Loup, Aurélien Dupeux, Renu Chandrasekaran, Jonathan Bajohr, C.H. Arrowsmith, Matthieu Schapira, Mark Lautens, Dalia Barsyte-Lovejoy, Rachel Harding, Vijayaratnam Santhakumar

The paper develops a chemical probe targeting the USP16 zinc-finger ubiquitin-binding domain and evaluates its selectivity and activity in cellular assays.

Journal of Medicinal Chemistry · Feb 20, 2026Peer-reviewedMolecular Biology

A resource to enable chemical biology and drug discovery of WDR Proteins

Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk, Almagul Seitova, P. Loppnau, Hong Zeng, Jin Hua Xu, Shabbir Ahmad, Yelena A. Arnautova, Arrash J. Baghaie, Serap Beldar, Albina Bolotokova, Paolo A. Centrella, Irene Chau, Matthew A. Clark, , C. H. Arrowsmith

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Journal of Medicinal Chemistry · Nov 4, 2024Peer-reviewedBiochemistry