Author

Serap Beldar

University of TorontoORCID 0000-0002-7601-4543Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Lindsey Ingerman JamesiD· 2 shared Angie L. MordantiD· 1 shared C.H. ArrowsmithiD· 1 shared Dalia Baršytė-LovejoyiD· 1 shared Devan J. ShelliD· 1 shared Dong ChengiD· 1 shared Fengling LiiD· 1 shared Jacqueline L. Norris-DrouiniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Lindsey Ingerman JamesORCID

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2 papers

Recent·Most cited

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

Mélanie Uguen, Devan J. Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M. Szewczyk, Ka Yang, Yani Zhao, Michael A. Stashko, Jacqueline L. Norris-Drouin, Jarod M. Waybright, Serap Beldar, Justin M. Rectenwald, Angie L. Mordant, Thomas S. Webb, , Stephen V. Frye

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

Nature Communications · Feb 24, 2025Peer-reviewedMolecular Biology

Structural basis for the binding selectivity of human CDY chromodomains

Dong Cheng, Yanli Liu, Tian‐Jie Lyu, Serap Beldar, Kelsey N. Lamb, W. Tempel, Yanjun Li, Zoey Li, Lindsey Ingerman James, Qin Su, Yun Wang, Jinrong Min

This study determines the structural basis for CDY chromodomain selectivity in binding lysine-methylated ARKS motifs, revealing distinct preferences for H3K9me3 and H3K27me3.

Cell chemical biology · May 28, 2020Peer-reviewedMolecular Biology