Mark Lautens

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.

Development of a dual chemical probe for the USP16 and HDAC6 zinc-finger ubiquitin-binding domain

The paper develops a chemical probe targeting the USP16 zinc-finger ubiquitin-binding domain and evaluates its selectivity and activity in cellular assays.

Diverse Plant-Parasitic Nematodes are Selectively Killed by Oxadiazole Thioether Pro-Nematicides

The paper discovers a pro-nematicide scaffold, Cyprocide, that selectively kills diverse plant-parasitic nematodes through P450 enzyme activation, offering a potential solution for sustainable nematode management.