Author

Rithik E. Castelino

National Institutes of HealthORCID 0000-0002-0034-9902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Anna J. WoodiD· 1 shared Anthony M. CianconeiD· 1 shared Francis J. O’ReillyiD· 1 shared Hitendra NegiiD· 1 shared Katerina Atallah-YunesiD· 1 shared Kitaik LeeiD· 1 shared Kylie J. WaltersiD· 1 shared Mary R. GuestiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Anna J. WoodORCID

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2 papers

Recent·Most cited

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy

Kitaik Lee, Hitendra Negi, Xiang Chen, Katerina Atallah-Yunes, Sunny Truslow, Rithik E. Castelino, Mary R. Guest, Anthony M. Ciancone, Xiuxiu Lu, Sergey G. Tarasov, Raj Chari, Kylie J. Walters, Francis J. O’Reilly

The paper uses PhIX-MS and cryo-EM to map transient interactions at proteasomes, revealing structural details of proteins like TXNL1 and PSMD5.

Molecular Cell · Jul 21, 2026Peer-reviewedCell Biology

Structure and inhibition of the sperm TMEM95-FIMP complex in mammalian fertilization

Pulan Liu, Rithik E. Castelino, Taylor R. Gierke, Anna J. Wood, Yonggang Lu, Shaogeng Tang

This study identifies FIMP as a binding partner of TMEM95, determines their complex structure, and shows that disrupting this interaction inhibits sperm-egg fusion.

bioRxiv · May 15, 2026 · PreprintBiochemistry