Shaogeng Tang

This paper uses a machine learning model to generate new anti-PD-1 antibodies with improved potency, validated through molecular dynamics simulations and experimental testing.

This study identifies a novel protein fold in KSHV ORF24 that enables direct binding to RNAPII CTD, facilitating viral late gene transcription through structural mimicry of a host transcription factor.

This study identifies FIMP as a binding partner of TMEM95, determines their complex structure, and shows that disrupting this interaction inhibits sperm-egg fusion.

This study reveals the structure and function of the cytoplasmic lattice in mammalian eggs, showing it sequesters ubiquitination machinery and tubulin for use during early embryonic development.

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.

This study shows human TMEM95 binds eggs, identifies a binding region via crystallography, and develops antibodies that impair sperm-egg fusion without blocking binding.

This study identifies 1700029I15Rik as a gene critical for the biosynthesis of acrosomal membrane proteins necessary for sperm-egg fusion in mice.