Yasuhiko Kawakami

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

Myocardial Endoglin Regulates Cardiomyocyte Proliferation and Cardiac Regeneration

The paper identifies Endoglin as an inhibitor of cardiomyocyte proliferation and shows its role in cardiac regeneration through genetic and mechanistic studies.

The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of human cardiomyocytes

This study identifies the HH-GLI2-CKS1B network as a regulator of the proliferation-to-maturation transition in human cardiomyocytes, with implications for cardiac regeneration.