Author

Myung Soo Ko

San Diego State UniversityORCID 0000-0002-0053-3697Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arshdeep SinghiD· 1 shared Divya Ramchandani· 1 shared Glenn E. Simmons Jr.iD· 1 shared Gourisankar GhoshiD· 1 shared Guoan Zhang· 1 shared Henry Withers· 1 shared Jason McCormickiD· 1 shared Liron YoffeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Arshdeep SinghORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.

Myung Soo Ko, Henry Withers, Divya Ramchandani, Jason McCormick, Sebastian E. Carrasco, Pius Amartey, Arshdeep Singh, Liron Yoffe, Glenn E. Simmons Jr., Guoan Zhang, Wen Hong Shen, Vivek Mittal

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

bioRxiv · Oct 30, 2026 · PreprintCancer Biology✦ In-depth digest

Cryo-EM reveals alternative modes of dimerization driving activation of IKK

Tapan Biswas, Shandy Shahabi, Xiang-Yang Zhong, Myung Soo Ko, Tom Huxford, Gourisankar Ghosh

This paper uses cryo-EM to show that IKK2/β adopts distinct dimeric conformations that regulate its activation through structural plasticity and interactions with NEMO and polyubiquitin.

bioRxiv · Jul 1, 2026 · PreprintImmunology