Lynette Beattie

Innate immune sensing of cell traversal by Plasmodium sporozoites drives protective T cell responses

The paper shows that Plasmodium sporozoites trigger innate immune responses via cell traversal, which is essential for activating protective CD8+ T cells.

Optimization of a liver Trm cell-inducing mRNA vaccine by reduction of type I interferon response

This study optimizes an mRNA vaccine to enhance liver Trm cell induction by reducing type I interferon responses through improved manufacturing.

Vγ1+ γδ T cell-derived IL-4 initiates CD8 T cell immunity

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

B cells targeting parasites capture spatially linked antigens to secure T cell help

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.

Defining the roles of NKG7 expressed by CD4+ and CD8+ T cells during malaria

This study investigates the role of NKG7 in CD4+ and CD8+ T cells during malaria, showing protective and cell-intrinsic functions in different infection models and human infections.

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination

This study shows that RAS vaccination generates long-lived liver-resident memory T cells specific for abundant sporozoite antigens, which mediate protection but may limit vaccine efficacy against diverse parasite strains.

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalling

This study shows that purinergic signaling via ARTC2 and P2RX7 regulates the survival and function of unconventional T cells, affecting IFN-γ and IL-4 production.