Romain Barrès

The paper introduces iSiT, an imaging-based spatial isoform transcriptomics method, and demonstrates its application in the mouse brain to study transcript isoform diversity at cellular and subcellular resolution.

This study shows that male obesity affects adipose mitochondrial function in offspring via the let-7-DICER axis, with reversible effects observed in both mice and human semen.

This study shows that increasing Cathepsin B in skeletal muscle of Alzheimer's mice improves memory and neurogenesis without affecting plaque pathology.

Nine vastus lateralis biopsies from before exercise to 48 h after one high-intensity interval session reveal 16,625 exercise-responsive genes; only four respond differently between males and females.

The paper examines how male mice's diet affects brown adipose tissue proteome and intergenerational effects on female offspring.

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

This study links a high fat low carbohydrate diet to protection against CNS autoimmunity by showing reduced neuroinflammation and immunometabolic changes in a mouse model.

The paper examines how childhood maltreatment affects sperm small non-coding RNA and DNA methylation profiles in humans, identifying specific epigenetic changes linked to trauma exposure.

The paper uses single-cell bisulfite sequencing to analyze DNA methylation in spermatozoa from lean and obese humans, revealing distinct epigenetic patterns that may affect intergenerational health outcomes.