Author

Hendrik B. Sager

Deutsches Herzzentrum MünchenORCID 0000-0002-0197-6553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Heribert SchunkertiD· 3 shared M. Amin SharifiiD· 3 shared Tan An DangiD· 3 shared Thorsten KessleriD· 3 shared Aldo MoggioiD· 2 shared Carla AbrahamianiD· 2 shared Christian GraesseriD· 2 shared Johannes Riechel· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPhysiology

Heribert SchunkertORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Antibody-mediated inhibition of ADAMTS-7 reduces experimental atherosclerosis

M. Amin Sharifi, Johannes Riechel, Michael J. Winkler, Tan An Dang, Christian Graesser, Philipp Müller, Carla Abrahamian, Nikita Panyam, Priscilla S. Briquez, Holger Spiegel, Hendrik B. Sager, Nicole P. G. Raven, Heribert Schunkert, Thorsten Kessler

This study develops a monoclonal antibody against ADAMTS-7 that reduces atherosclerosis in mice without affecting lipid levels or causing toxicity.

bioRxiv · Aug 19, 2026 · PreprintPhysiology

Cigarette smoking upregulates vascular expression of the novel atherosclerosis risk factor ADAMTS-7

Carla Abrahamian, M. Amin Sharifi, Tan An Dang, Aldo Moggio, Michael J. Winkler, Johannes Riechel, Hanna Winter, Baiba Vilne, Simone Kraut, Stefan Hadžić, Cheng‐Yu Wu, Irina Pugach, Marija Gredic, M Fassbender, Julia Hinterdobler, , Thorsten Kessler

This study shows cigarette smoke increases vascular ADAMTS7 expression through CCL17-CCR4 signaling, linking smoking to atherosclerosis via a novel gene-environment interaction.

bioRxiv · Oct 28, 2025 · PreprintPhysiology

The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

M. Amin Sharifi, Michael Wierer, Tan An Dang, Jelena Milic, Aldo Moggio, Nadja Sachs, Moritz von Scheidt, Julia Hinterdobler, Philipp Müller, Julia Werner, Barbara Stiller, Zouhair Aherrahrou, Jeanette Erdmann, Andrea Zaliani, Mira Graettinger, , Thorsten Kessler

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

bioRxiv · Mar 6, 2023 · PreprintMolecular Biology