Jonathan Thomas Lei

This study shows that TNBC cells surviving ionizing radiation adopt an OPA1-dependent mitochondrial reprogramming that supports their survival and regrowth.

This study identifies OXA1L-dependent mitochondrial translation as a targetable dependency in chemo-refractory TNBC, showing that inhibiting it enhances chemotherapy sensitivity.

This paper evaluates kinase activity inference methods using phosphoproteomics data and benchmarking approaches, finding that curated kinase-substrate libraries significantly impact results.

This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.

DeepRescore2 improves phosphopeptide identification using deep learning, leading to more phosphosites detected and new biological insights in liver cancer.

This study identifies how specific cell cycle checkpoint kinase dysregulations influence cancer subtype, metastasis, and treatment response in breast cancer.