Karen Wang

Human lymphatic organoids reconstruct convergent developmental routes to functional lymphatic vessels

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

Mitochondrial rewiring supports survival of triple negative breast cancer cells after ionizing radiation

This study shows that TNBC cells surviving ionizing radiation adopt an OPA1-dependent mitochondrial reprogramming that supports their survival and regrowth.

Mitochondrial translation is a targetable dependency of chemo-refractory triple negative breast cancer

This study identifies OXA1L-dependent mitochondrial translation as a targetable dependency in chemo-refractory TNBC, showing that inhibiting it enhances chemotherapy sensitivity.

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

Diverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers

This study investigates the roles of PlexinA2, PlexinA4, and NCAM in the development of mossy fibers in the hippocampus, revealing distinct and overlapping functions in axon bundling and targeting.

RM1mAb avoids Intracellular degradation to Synergistically inhibit NLRP3 Inflammasome Activation in Familial Cold Autoinflammatory Syndrome

RM1mAb and TH5487 synergistically inhibit inflammasome activation in human FCAS PBMCs by preventing NLRP3-mtDNA interaction and avoiding lysosomal degradation.