Yong Zhou

This study shows that lipid acyl chain remodeling via LPCAT3 affects KRAS nanoclustering and oncogenic activity by altering membrane composition.

This study shows that KRAS G12C and G12D mutants respond differently to lipid acyl chain remodeling, affecting their nanoclustering and signaling activities.

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

The paper develops a method to isolate autophagosomes from mice and uses proteomics to analyze cargo profiles in skeletal muscle during starvation and exercise, identifying distinct cargo selection patterns.

The paper shows that RAS G-domains influence the sorting of phosphatidylserine acyl chains in the plasma membrane, with different mutants sorting distinct PS species.

This study shows that K-Ras and H-Ras isoforms respond differently to plasma membrane curvature, with K-Ras favoring less curved membranes and H-Ras favoring more curved membranes, mediated by phospholipid sorting.