Author

Todd A. MacKenzie

Dartmouth CollegeORCID 0000-0002-0215-2003Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Todd A. MacKenzie1 paper

Biology Disciplines

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Pathology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adrienne A. WorkmaniD· 1 shared Alexander V. AlekseyenkoiD· 1 shared Amanda B. Nymon· 1 shared Antonis KourtidisiD· 1 shared Bruce A. StantoniD· 1 shared Candice C. BlackiD· 1 shared Carolyn Roche· 1 shared Christine E. BookhoutiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperPathology

Adrienne A. WorkmanORCID

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3 papers

Recent·Most cited

X-SPATIO: An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer

V. Madhusudhan Rao, Madhumala K. Sadanandappa, Candice C. Black, Scott M. Palisoul, Adrienne A. Workman, Todd A. MacKenzie, Xiaoying Liu, Mary Dickinson Chamberlin, Louis Joseph Vaickus, George J. Zanazzi, Shrey Sukhadia

X-SPATIO predicts and visualizes spatially resolved biomarker expression in TNBC by linking H&E morphology with spatial transcriptomic and proteomic data.

bioRxiv · Feb 11, 2026 · PreprintPathology

Differences in T-cell counts and neighborhood patterns in human colorectal adenomas and sessile serrated lesions

Souvik Seal, Lauren Rose Fanning, Evan M. Bagley, Christine E. Bookhout, Elizabeth L. Barry, Elizabeth C. O’Quinn, Dale C. Snover, David Lewin, Silvia Guglietta, Antonis Kourtidis, Martha J. Shrubsole, John A. Baron, Todd A. MacKenzie, Alexander V. Alekseyenko, Kristin Wallace

The paper compares T-cell counts and spatial patterns in colorectal adenomas and sessile serrated lesions, finding differences in T-cell infiltration and clustering by lesion type.

bioRxiv · Jan 6, 2026 · PreprintPathology

Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function

Thomas H. Hampton, Roxanna Barnaby, Carolyn Roche, Amanda B. Nymon, Kiyoshi F. Fukutani, Todd A. MacKenzie, Lily A. Charpentier, Bruce A. Stanton

This study shows ETI increases defensin gene expression and reduces MMP10, MMP12, and inflammatory signaling in CF airway epithelial cells.

American Journal of Physiology-Lung Cellular and Molecular Physiology · Oct 22, 2024Peer-reviewedPharmacology & Toxicology