Stefan C. Dentro

The history of chromosomal instability in genome doubled tumors

This paper introduces GRITIC, a method to time genomic gains in tumors, finding that copy number gains often accumulate after genome duplication.

Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction

The paper benchmarks 31 subclonal reconstruction algorithms on simulated tumours, finding that algorithm choice significantly impacts performance and no single algorithm excels across all tasks.

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

The paper analyzes whole-genome data from Nigerian breast cancer patients, identifying ethnic-driven somatic evolution and distinct genomic subtypes associated with African ancestry.

Creating Standards for Evaluating Tumour Subclonal Reconstruction

This study develops quantitative metrics and simulated datasets to evaluate subclonal reconstruction methods in tumours.

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours

The paper analyzes somatic retrotransposition events in 2,954 cancer genomes, identifying L1 insertions as significant contributors to structural variations and oncogenesis.