Jean‐Pierre Kocher

This paper presents near-complete, haplotype-resolved assemblies of a pancreatic cancer genome and normal tissue, identifying extensive somatic variants and epigenetic changes in previously excluded regions.

Immunopipe provides a flexible pipeline for integrated analysis of scRNA-seq and scTCR-seq data to enhance understanding of T-cell immunity and immunotherapy.

This study removes a hexanucleotide repeat expansion in C9ORF72 using CRISPR/Cas9 in cell and animal models, reducing disease hallmarks.

Exogene detects viral integrations from paired-end sequencing data with high concordance to long-read validation, identifying new integrations in HCC samples.

The paper demonstrates that transplanting corrected hepatocytes into mesenteric lymph nodes cures a pig model of tyrosinemia by repopulating the diseased liver and restoring liver function.

This paper improves coverage profile correction in shallow-depth ccfDNA WGS using multi-distance learning, reducing variability and improving trisomy screening performance.

CircularLogo visualizes intra-motif dependencies in DNA/RNA sequences through an interactive web application.