Author

Liis Uusküla-Reimand

SickKids FoundationORCID 0000-0002-5322-5524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:variant calling· 2

Frequent Co-Authors

Huayun HouiD· 3 shared Michael D. WilsoniD· 3 shared Anna GoldenbergiD· 2 shared Anna R. Roy· 2 shared Cadia ChaniD· 2 shared Christina CorreiD· 2 shared Dustin SokolowskiiD· 2 shared Jüri ReimandiD· 2 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenomics

Huayun HouORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes

Liis Uusküla-Reimand, Christian A. Lee, Robin Hyunseo Oh, Zoe P. Klein, Nina Adler, Sana Akhtar Alvi, Ellen R. Langille, Elisa Pasini, Kevin C.L. Cheng, Evgenija Serafimova, Diala Abd-Rabbo, Huayun Hou, Ricky Tsai, Mamatha Bhat, Daniel Schramek, , Jüri Reimand

The paper identifies TOP2B binding sites as mutational hotspots in cancer genomes, showing their role in structural variants and driver mutations in genes like TP53 and MYC.

Nature Communications · Nov 21, 2025Peer-reviewedCancer Biology

Age, sex, and cell type-resolved hypothalamic gene expression across the pubertal transition in mice

Dustin Sokolowski, Huayun Hou, Kyoko E. Yuki, Anna R. Roy, Cadia Chan, Wendy W. Y. Choi, Mariela Faykoo-Martinez, Matt Hudson, Christina Corre, Liis Uusküla-Reimand, Anna Goldenberg, Mark R. Palmert, Michael D. Wilson

The paper analyzes hypothalamic gene expression in mice across puberty, identifying age- and sex-specific changes and their association with pubertal regulation.

Biology of Sex Differences · Oct 24, 2024Peer-reviewedGenomics

Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland

Huayun Hou, Cadia Chan, Kyoko E. Yuki, Dustin Sokolowski, Anna R. Roy, Rihao Qu, Liis Uusküla-Reimand, Mariela Faykoo-Martinez, Matt Hudson, Christina Corre, Anna Goldenberg, Zhaolei Zhang, Mark R. Palmert, Michael D. Wilson

This study profiles gene and miRNA expression in mouse pituitaries across postnatal ages to identify sex-biased gene regulation and cell-type proportion differences during development.

bioRxiv · Jan 5, 2022 · PreprintGenomics

Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes

Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Lynge Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, , Gad A. Getz

The paper identifies and characterizes coding and non-coding driver mutations across 2,500 cancer genomes, revealing new candidates and questioning previous findings.

bioRxiv · Dec 23, 2017 · PreprintGenomics