Author

Christian A. Lee

Ontario Institute for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Diala Abd-RabboiD· 2 shared Jüri ReimandiD· 2 shared Daniel SchramekiD· 1 shared Elisa PasiniiD· 1 shared Ellen R. LangilleiD· 1 shared Evgenija Serafimova· 1 shared Huayun HouiD· 1 shared Kevin C.L. ChengiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Diala Abd-RabboORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes

Liis Uusküla-Reimand, Christian A. Lee, Robin Hyunseo Oh, Zoe P. Klein, Nina Adler, Sana Akhtar Alvi, Ellen R. Langille, Elisa Pasini, Kevin C.L. Cheng, Evgenija Serafimova, Diala Abd-Rabbo, Huayun Hou, Ricky Tsai, Mamatha Bhat, Daniel Schramek, , Jüri Reimand

The paper identifies TOP2B binding sites as mutational hotspots in cancer genomes, showing their role in structural variants and driver mutations in genes like TP53 and MYC.

Nature Communications · Nov 21, 2025Peer-reviewedCancer Biology

Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes

Christian A. Lee, Diala Abd-Rabbo, Jüri Reimand

The paper characterizes mutation rate variability in regulatory elements across cancer genomes and identifies mutational signatures and drivers associated with specific genomic features.

Genome biology · May 3, 2021Peer-reviewedGenomics