Stephen M. Smith

P/Q-type voltage-gated calcium channels regulate calcium signaling and developmental myelination in oligodendrocyte lineage cells

This study investigates the role of P/Q-type voltage-gated calcium channels in oligodendrocyte lineage cells during myelination in zebrafish, finding that these channels are essential for normal myelination and calcium signaling.

Unreliable homeostatic action potential broadening in cultured dissociated neurons

The paper shows that chronic inactivity does not broadly affect action potentials in neocortical neurons but does in hippocampal neurons under specific conditions.

Anandamide reduces excitability by preferentially targeting somatic VGSCs via CB1

The paper identifies a pathway by which anandamide inhibits neuronal excitability through somatic VGSCs via CB1 activation in neocortical neurons.

Inactivated voltage-gated sodium channels are preferentially targeted in cinacalcet block of mouse neocortical action potentials

This study investigates how cinacalcet inhibits voltage-gated sodium channels in mouse neocortical neurons, showing it preferentially targets fast-inactivated states and alters neuronal excitability non-linearly.

CaSR modulates sodium channel-mediated Ca 2+ -dependent excitability

The paper investigates how extracellular calcium affects neuronal excitability and finds that the Calcium-sensing receptor (CaSR) modulates voltage-gated sodium channel (VGSC) activity, influencing action potential firing rates.

Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons

The paper reports direct recordings of presynaptic action potentials in neocortical boutons, showing differential broadening in excitatory and inhibitory neurons.