Martin Heine

Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation.

This paper shows that presynaptic filopodia, driven by activity, calcium, and actin, physically modulate membrane mechanics to enhance synchronous neurotransmission and contribute to seizure generation.

Bassoon is required for adult ocular dominance plasticity and experience-induced changes in synapsin phosphorylation in visual cortex

This study shows that bassoon is essential for adult ocular dominance plasticity but not juvenile plasticity, involving presynaptic changes in synapsin phosphorylation.

Fast calcium-dependent fluorescent labeling for recording of neuronal activation

The paper introduces faster variants of the Caprola tool for calcium-dependent fluorescent labeling, enabling more sensitive and efficient recording of neuronal activity in zebrafish.

Functional relevance of mobile and clustered CaV2.1 channels in central synapses

The paper shows that mobile CaV2.1 channels enhance neurotransmitter release reliability at higher frequencies and are inhibited by GABABR activation.

Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation

This study shows that octopamine rapidly potentiates presynaptic neurotransmitter release in Drosophila by clustering Unc13 via diacylglycerol signaling, affecting synaptic function and behavior.

Unreliable homeostatic action potential broadening in cultured dissociated neurons

The paper shows that chronic inactivity does not broadly affect action potentials in neocortical neurons but does in hippocampal neurons under specific conditions.

Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms

This study shows that alternative splicing of the Drosophila Cav2 gene regulates distinct presynaptic functions, with different splice variants affecting synaptic vesicle release and short-term plasticity.

Activity-Dependent Localization and Heterogeneous Dynamics of STIM1 and STIM2 at ER-PM contacts in Hippocampal Neurons.

The paper investigates the dynamic localization and activity-dependent behavior of STIM1 and STIM2 at ER-PM contacts in hippocampal neurons, revealing their heterogeneous dynamics and differential recruitment under different conditions.

miRNA-mediated expression of RBFOX2 governs the splicing transition from progenitors to neurons in the developing brain

This study identifies miR-92a-3p as a regulator of RBFOX2 expression, which controls the splicing transition from neural progenitors to neurons in the developing mouse cortex.

Cortexa - a comprehensive resource for studying gene expression and alternative splicing in the murine brain.

Cortexa provides a web-portal with standardized RNA-sequencing data and tools for analyzing gene expression and alternative splicing in the mouse brain.

Neuroimage Denoiser for removing noise from transient fluorescent signals in functional imaging.

Neuroimage Denoiser removes noise from functional microscopy recordings, improving neural activity analysis by preserving signal amplitude and operating without re-training for different sensors.

Identification and characterization of a synaptic active zone assembly protein

This study identifies Blobby as a novel regulator of presynaptic active zone nanopatterning and shows its role in maintaining Ca2+ channel packing density and synaptic function.

Inhibiting presynaptic calcium channel mobility in the auditory cortex suppresses synchronized input processing

The paper investigates how inhibiting presynaptic calcium channel mobility in the auditory cortex affects synchronized input processing and reveals its role in adjusting network activity across synaptic input strengths.