The paper analyzes longitudinal body weight data in mice to identify traits linked to lifespan, finding heritable traits associated with energy homeostasis and longevity.

Nature Communications · Jan 19, 2026Peer-reviewedPhysiology

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Andrea Di Francesco, Andrew G. Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, Laura L. Robinson, Gaven Garland, Hannah Donato, Matthew J. Vincent, Will Schott, Kevin M. Wright, Anil Raj, G.V. Prateek, Martin N. Mullis, Warren G. Hill, , Gary A. Churchill

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Nature · Oct 9, 2024Peer-reviewedGenetics✦ In-depth digest

Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

Zhenghao Chen, Anil Raj, G.V. Prateek, Andrea Di Francesco, Justin Liu, Brice E. Keyes, Ganesh Kolumam, Vladimir Jojic, Adam Freund

This study develops a high-dimensional phenotyping platform to evaluate physiological aging and resilience in mice, finding that aging begins early and resilience declines with age.

eLife · Mar 30, 2022Peer-reviewedSystems Biology