Laura L. Robinson

Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice

Mass spectrometry of Mag-Net-enriched plasma extracellular vesicles from 86 C57BL/6J mice reveals 272 age-correlated proteins, sex-divergent trajectories, and an age clock with 2.75-month mean absolute error.

A multiomic lifespan signature in genetically diverse, diet-restricted mice

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

Genetic regulation of fasting-induced longevity effects

This study shows that genetic background and sex influence responses to intermittent fasting in mice, with effects on lifespan and health outcomes varying across strains.

Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci

This study identifies six longevity-associated loci in Diversity Outbred mice through a genetic meta-analysis of lifespan data from three studies, explaining over half of the heritable variation in lifespan.

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Longitudinal Fragility phenotyping predicts lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice

This study uses frailty phenotyping to predict lifespan and age-associated morbidity in mice, finding it has significant predictive power but not sufficient reliability for advanced lifespan prediction.

Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice

This study examines how caloric restriction and intermittent fasting interact with genetics to influence physiological health in mice, finding diet-specific effects and significant genetic contributions to multiple traits.