Author

Andrew G. Deighan

Jackson LaboratoryORCID 0000-0002-7378-8463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gary A. ChurchilliD· 4 shared Adam FreundiD· 3 shared Anil RajiD· 3 shared Kevin M. WrightiD· 3 shared Andrea Di FrancescoiD· 2 shared Gaven Garland· 2 shared Hannah Donato· 2 shared Laura L. Robinson· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Gary A. ChurchillORCID

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4 papers

Recent·Most cited

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Andrea Di Francesco, Andrew G. Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, Laura L. Robinson, Gaven Garland, Hannah Donato, Matthew J. Vincent, Will Schott, Kevin M. Wright, Anil Raj, G.V. Prateek, Martin N. Mullis, Warren G. Hill, , Gary A. Churchill

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Nature · Oct 9, 2024Peer-reviewedGenetics✦ In-depth digest

Age and diet shape the genetic architecture of body weight in Diversity Outbred mice

Kevin M. Wright, Andrew G. Deighan, Andrea Di Francesco, Adam Freund, Vladimir Jojic, Gary A. Churchill, Anil Raj

The paper quantifies diet-dependent genetic contributions to body weight in mice and identifies loci associated with age- and diet-dependent body weight variation.

eLife · May 23, 2022Peer-reviewedGenetics

Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart

Isabela Gerdes Gyuricza, Joel M. Chick, Gregory R. Keele, Andrew G. Deighan, Steven C. Munger, Ron Korstanje, Steven P. Gygi, Gary A. Churchill

The paper analyzes transcriptome and proteome data from aged mouse hearts to identify molecular changes associated with aging, revealing distinct biological processes and genetic loci influencing age-related changes.

Genome Research · Mar 11, 2022Peer-reviewedGenomics

Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice

Guozhu Zhang, Andrew G. Deighan, Anil Raj, Laura L. Robinson, Hannah Donato, Gaven Garland, Mackenzie Leland, Baby Martin-McNulty, Ganesh A. Kolumam, Johannes Riegler, Adam Freund, Kevin M. Wright, Gary A. Churchill

This study examines how caloric restriction and intermittent fasting interact with genetics to influence physiological health in mice, finding diet-specific effects and significant genetic contributions to multiple traits.

Genetics · Sep 25, 2021Peer-reviewedGenetics