Alison Luciano

A prediction-interval framework for identifying outlier control cohorts in lifespan studies

The paper develops a prediction-interval framework to identify outlier control cohorts in lifespan studies using data from the National Institute on Aging Interventions Testing Program.

Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice

Mass spectrometry of Mag-Net-enriched plasma extracellular vesicles from 86 C57BL/6J mice reveals 272 age-correlated proteins, sex-divergent trajectories, and an age clock with 2.75-month mean absolute error.

A multiomic lifespan signature in genetically diverse, diet-restricted mice

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

Multimodal analysis of molecular remodeling in aging spleen identified global and cell type specific changes

The paper identifies age-related molecular changes in mouse spleens using proteomics and transcriptomics, showing cell-type-specific remodeling and gender differences in post-transcriptional buffering.

Genetic regulation of fasting-induced longevity effects

This study shows that genetic background and sex influence responses to intermittent fasting in mice, with effects on lifespan and health outcomes varying across strains.

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Quantifying the Impact of Co-Housing on Murine Aging Studies

The paper assesses the impact of co-housing on lifespan studies in mice, showing that outcomes are correlated within housing units and highlighting limitations of standard statistical models.

Longitudinal Fragility phenotyping predicts lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice

This study uses frailty phenotyping to predict lifespan and age-associated morbidity in mice, finding it has significant predictive power but not sufficient reliability for advanced lifespan prediction.