Matthew J. Vincent

Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism

The paper identifies genetic regulators of the murine serum metabolome, highlighting carboxyl esterases as key controllers of fatty acid metabolism.

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools

The paper identifies genetic factors influencing red blood cell proteome and oxidative stress in mice, highlighting hemoglobin cysteine redox status as critical for glutathione regulation.

Modeling metabolic disease susceptibility and resilience in genetically diverse mice

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

Ferroptosis regulates hemolysis in stored murine and human red blood cells

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Detecting isoform-level allelic imbalance accounting for inferential uncertainty

The paper introduces SEESAW, a method to detect isoform-level allelic imbalance while accounting for inferential uncertainty, and evaluates it on simulated and real RNA-seq data.

QTLViewer: An interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations

QTLViewer provides an interactive webtool for QTL mapping and exploration in CC and DO mouse populations, enhancing accessibility to genetic analysis resources.

Multi-omics analysis identifies drivers of protein phosphorylation

The paper identifies genetic drivers of protein phosphorylation using multi-omics data from mouse tissues, revealing novel interactions and targets of PDK1 in obesity and diabetes.

Regulation of protein abundance in genetically diverse mouse populations

The paper analyzes liver proteomes across three genetically diverse mouse populations to understand how genetic variation influences protein abundance and its relationship to phenotypes.

Decoupling alignment strategy from feature quantification using a standard alignment incidence data structure

The paper introduces a data structure and file format for alignment incidence data to enable flexible and optimal pipelines for read alignment, QC, and quantification across sequencing modalities.

Genetic variation influences pluripotent ground state stability in mouse embryonic stem cells through a hierarchy of molecular phenotypes

The paper identifies genetic variants influencing metastability in mouse embryonic stem cells by analyzing gene expression and chromatin accessibility in 185 genetically diverse cells.

Hierarchical Analysis of Multi-mapping RNA-Seq Reads Improves the Accuracy of Allele-specific Expression

EMASE improves ASE estimation by hierarchically allocating multi-mapping RNA-Seq reads, showing better performance than standard methods in simulations and detecting ASE in F1 hybrid mice.

The Effects of Sex and Diet on Physiology and Liver Gene Expression in Diversity Outbred Mice

This study examines how sex and diet influence physiology and liver gene expression in Diversity Outbred mice, identifying genetic and sex-by-diet interactions affecting metabolic traits.