Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity
Hargobinder Kaur, Rebekah B. Guevara, Yolanda Rivera-Cuevas, Einar B. Olafsson, Joshua Mayoral, Leonardo da Silva Augusto, Alfredo J. Guerra, Romir K. Patel, Kevin Patrick Bohannon, Jonathan Z. Sexton, Phyllis I. Hanson, Louis M. Weiss, Vern B. Carruthers
This paper identifies TgGRA8 as a Toxoplasma protein that recruits ALG-2 to the parasitophorous vacuole, essential for parasite metabolism and ESCRT hijacking.
bioRxiv · Jul 23, 2026 · PreprintCell Biology