Fan Zheng

The Spatiotemporal Proteome Landscape of Aging: Structural determinants of age-sensitive proteome remodeling

The paper uses yeast aging to map proteome changes across age, revealing structural determinants of age-sensitive remodeling and providing a resource for aging research.

Single-Cell Spatial Proteomics Uncovers Molecular Interconnectivity among Hallmarks of Aging

The paper uses single-cell spatial proteomics in yeast to uncover molecular changes linked to aging hallmarks and their spatial organization.

Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation

The paper shows that desmosome mutations in keratinocytes of the tumor microenvironment promote melanoma proliferation through reduced desmosome gene expression and increased melanoma cell growth.

Mapping cell structure across scales by fusing protein images and interactions

The paper integrates protein imaging and interaction data to create a unified map of eukaryotic cell structure, revealing new subcellular systems and protein associations.

Proteome plasticity in response to persistent environmental change

This study shows that budding yeast adapts to long-term high temperature by reducing temperature-sensitive proteins, relocalizing the proteome, and altering protein conformations, which may confer new functions.

Identifying persistent structures in multiscale 'omics data

This paper introduces a method to identify persistent structures in multiscale omics data, expanding cell type catalogs and revealing SARS-COV-2 protein interactions.