Caroline C. Escoubas

NOVA is an R-package for analyzing MEA data, offering dimensionality reduction, clustering, and trajectory mapping, revealing network burst duration as a key activity metric.

This study shows that microglial cathepsin B is essential for efficient neuronal efferocytosis during brain development, preventing apoptotic cell accumulation and ensuring proper neural circuit formation.

This study shows that group 2 innate lymphoid cells (ILC2s) and their cytokine IL-13 promote inhibitory synapse development and adult social behavior.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

This study shows that AMPK enhances associative learning in C. elegans by promoting neuronal mitochondrial fusion, which is critical for maintaining neuronal function with age and in neurodegenerative conditions.