Author

Miriam C. McDonough

University of IowaORCID 0000-0002-0481-324XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jon M. ReschiD· 3 shared Joel C. GeerlingiD· 2 shared Silvia GaspariniiD· 2 shared Ahmet KuralayiD· 1 shared Berns Alysia· 1 shared Chidera J.A. Mitchell· 1 shared Ethan BahliD· 1 shared Jacob J. MichaelsoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Jon M. ReschORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aldosterone drives HSD2 neuron activity and molecular remodeling of synaptic function to promote sodium appetite

Miriam C. McDonough, Ahmet Kuralay, Trevor C. Butler, Berns Alysia, Schwager Madelin, Silvia Gasparini, Joel C. Geerling, Jon M. Resch

The paper shows aldosterone enhances synaptic transmission in HSD2 neurons through SV2C, driving sodium appetite.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

HSD2 neurons are evolutionarily conserved and required for aldosterone-induced salt appetite

Silvia Gasparini, Lila Peltekian, Miriam C. McDonough, Chidera J.A. Mitchell, Marco M. Hefti, Jon M. Resch, Joel C. Geerling

The paper identifies HSD2 neurons in the human brain and demonstrates their necessity for aldosterone-induced salt intake in mice.

JCI Insight · Oct 24, 2024Peer-reviewedNeuroscience

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

Ethan Bahl, Snehajyoti Chatterjee, Utsav Mukherjee, Muhammad Elsadany, Yann S. Vanrobaeys, Li‐Chun Lin, Miriam C. McDonough, Jon M. Resch, Karl-Peter Giese, Ted G. Abel, Jacob J. Michaelson

NEUROeSTIMator uses deep learning to estimate neuronal activation from single-cell and spatial transcriptomic data, showing robustness across species and brain regions.

Nature Communications · Jan 26, 2024Peer-reviewedBioinformatics