Jon M. Resch

Aldosterone drives HSD2 neuron activity and molecular remodeling of synaptic function to promote sodium appetite

The paper shows aldosterone enhances synaptic transmission in HSD2 neurons through SV2C, driving sodium appetite.

A hypothalamic circuit for anticipating future changes in energy balance.

The paper shows that environmental cues predicting future fasting rapidly activate AgRP neurons via a circuit involving PVHSim2 neurons.

Sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.

This study identifies a subset of hippocampal CA1 pyramidal neurons that are selectively reactivated by repeated sleep deprivation and shows associated molecular changes.

Diverse activity in prefrontal projections promotes temporal control of action

The paper investigates prefrontal projections during interval timing, finding distinct temporal coding and transcriptomic profiles in PFC-MD and PFC-DMS circuits.

HSD2 neurons are evolutionarily conserved and required for aldosterone-induced salt appetite

The paper identifies HSD2 neurons in the human brain and demonstrates their necessity for aldosterone-induced salt intake in mice.

A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution

This study creates a spatially-resolved transcriptional atlas of the murine dorsal pons using snRNA-seq and MERFISH, identifying 120 neuronal subtypes and their spatial distribution.

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

NEUROeSTIMator uses deep learning to estimate neuronal activation from single-cell and spatial transcriptomic data, showing robustness across species and brain regions.