Author

Michael U. Musheev

Institute of Molecular BiologyORCID 0000-0002-0499-9689Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Christof NiehrsiD· 4 shared Amitava BasuiD· 2 shared Lars SchomacheriD· 2 shared Anke BuschiD· 1 shared Antje Ostareck‐LedereriD· 1 shared Bernhard LüscheriD· 1 shared Carola Scholz· 1 shared Christoph DieterichiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

Christof NiehrsORCID

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4 papers

Recent·Most cited

Human PARPs modify RNA nucleobases in vitro and in cells

Michael U. Musheev, Jonas Siefert, Wiwik Bauten, Mareike Bütepage, Bernhard Lüscher, Christof Niehrs, Karla L. H. Feijs, Roko Žaja

This study shows PARP10 and PARP15 modify RNA nucleobases in vitro and in cells, and TARG1 reverses these modifications.

bioRxiv · Mar 31, 2026 · PreprintBiochemistry

PARP1 Writes N3-Cytidine ADP-Ribosylation in DNA

Michael U. Musheev, Lars Schomacher, Johanna M. Schott, Amitava Basu, Martin Möeckel, Sabine Heinen, Laura Frosch, Peng Guo, Gaofan Yang, Qiuya Huang, Christof Niehrs

This study identifies PARP1's ability to ADP-ribosylate N3-deoxycytidine in ssDNA, leading to deamination products detectable by LC-MS/MS.

bioRxiv · Dec 19, 2025 · PreprintBiochemistry

Mammalian N1-adenosine PARylation is a reversible DNA modification

Michael U. Musheev, Lars Schomacher, Amitava Basu, Dandan Han, Laura Krebs, Carola Scholz, Christof Niehrs

The paper demonstrates that mammalian DNA undergoes reversible N1-adenosine PARylation, identified through mass spectrometry and enzymatic analysis.

Nature Communications · Oct 17, 2022Peer-reviewedMolecular Biology

Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning

Nadine Körtel, Cornelia Rücklé, You Zhou, Anke Busch, Peter Hoch-Kraft, F.X. Reymond Sutandy, Jacob Haase, Mihika Pradhan, Michael U. Musheev, Dirk H. Ostareck, Antje Ostareck‐Lederer, Christoph Dieterich, Stefan Hüttelmaier, Christof Niehrs, Oliver Rausch, , Kathi Zarnack

The paper improves m6A RNA modification detection using miCLIP2 and m6Aboost, identifying thousands of high-confidence sites in human and mouse cells without requiring Mettl3 depletion.

Nucleic Acids Research · Jun 7, 2021Peer-reviewedGenomics