Kathrin Schumann

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells

This study identifies SATB1 as a regulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells, showing its potential as a target for CAR T cell therapy.

Reprogramming human T cell function and specificity with non-viral genome targeting

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.

A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors

The paper describes a CRISPR-Cas9 platform for editing primary CD4+ T cells to study HIV host factors, enabling high-throughput gene manipulation and downstream analysis.

Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation

The paper identifies an IL2RA enhancer associated with autoimmunity using CRISPRa and shows it affects gene activation timing without blocking expression.