Hannah A. Grunwald

Late embryonic expansion of a novel bone ridge underlies the evolutionary transformation of cylindrically shaped forelimb bones into the flattened skeleton of the penguin flipper

The paper identifies late embryonic developmental changes in penguin forelimbs that lead to flattened bone morphology and reduced musculature, driven by molecular programs associated with tendon-attachment sites.

CRISPR-mediated conditional mutagenesis of Smad1/5/8 reveals BMP/GDF signaling restricts postnatal bone overgrowth

This paper uses CRISPR-mediated conditional mutagenesis to show BMP/GDF signaling restricts postnatal bone overgrowth by regulating both periosteal and endosteal osteoblasts.

Meiotic Cas9 expression mediates genotype conversion in the male and female mouse germline

This study shows that meiotic Cas9 expression can mediate genotype conversion in both male and female mouse germlines, but low Cas9 levels limit efficiency.

Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline

This paper demonstrates that CRISPR/Cas9 can mediate super-Mendelian inheritance in female mouse germline through homology-directed repair.