Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats
Hélène Tonnelé, Denghui Chen, Felipe Morillo, Jorge Garcia-Calleja, Apurva S. Chitre, Benjamin B. Johnson, Thiago Missfeldt Sanches, Riyan Cheng, Marc Jan Bonder, Antonio González, Tomasz Kościółek, Anthony M. George, Wenyan Han, Katie Holl, Aidan P. Horvath, , Amelie Baud
The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.
Nature Communications · Dec 18, 2025Peer-reviewedGenetics