This study shows that TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells during murine pregnancy, supporting reproductive success.

eLife · Jul 8, 2026Peer-reviewedImmunology

CD8+ T cells are primed by cDC1 and exacerbate tau-mediated neurodegeneration

Hao Hu, Peter Bor‐Chian Lin, Carisa Zeng, Prabal Sharma, Yongyi Li, Hong Jiang, Jonathan Nulman, Ray A. Ohara, Tong Wu, Shasha Li, Wayne M. Yokoyama, Maxim N. Artyomov, KENNETH M. M. MURPHY, Jason D. Ulrich, David M. Holtzman

This study shows that cDC1 cells prime CD8+ T cells, which then exacerbate tau-mediated neurodegeneration in mice.

bioRxiv · Mar 1, 2026 · PreprintNeuroscience

Eomesodermin defines uterine NK cells crucial for pregnancy success in mice

Josselyn D Barahona, Liping Yang, Wayne M. Yokoyama

This study identifies Eomesodermin as essential for the development of uterine NK cells in mice, showing their critical role in successful pregnancy.

The Journal of Immunology · Jul 28, 2025Peer-reviewedImmunology

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

Sytse J. Piersma, Shasha Li, Pamela Wong, Michael D. Bern, Jennifer Poursine‐Laurent, Liping Yang, Diana L. Beckman, Bijal A. Parikh, Wayne M. Yokoyama

This study shows that a single inhibitory Ly49 receptor is sufficient to license NK cells and mediate missing-self recognition in vivo.

eLife · Sep 26, 2024Peer-reviewedImmunology