Hong Jiang

Autophagosome-tethering compounds selectively lower mutant ataxin-3 in preclinical models of spinocerebellar ataxia type 3

Small-molecule autophagosome-tethering compounds selectively lower mutant ataxin-3 through an LC3- and autophagy-dependent mechanism and improve disease-related phenotypes in preclinical models of SCA3.

CD8+ T cells are primed by cDC1 and exacerbate tau-mediated neurodegeneration

This study shows that cDC1 cells prime CD8+ T cells, which then exacerbate tau-mediated neurodegeneration in mice.

Strategic stabilization of arousal boosts sustained attention

The paper investigates how arousal and task utility interact to influence sustained attention in mice, finding that arousal stabilizes near optimal levels during high task utility.

A common flanking variant is associated with enhanced meiotic stability of the FGF14-SCA27B locus

The paper identifies a common flanking variant linked to increased meiotic stability at the FGF14-SCA27B repeat locus.

Herb-CMap: Novel Hot Diffusion Algorithm to Identify Bioactive Ingredients from Herbal Medicine Based on Gene Perturbation Profiling

Herb-CMap identifies bioactive ingredients in herbal medicine by integrating gene perturbation data with a random walk algorithm, revealing molecular mechanisms of action for treating cough variant asthma.

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.