Guangming Wu

This study identifies Pcbp1's role in enhancing amino acid metabolism during the naive-to-primed pluripotency transition, linking its deficiency to embryo growth arrest and reduced protein synthesis.

The paper shows that embryonic stem cells use asymmetric division in a two-cell-like state to rejuvenate and maintain lineage immortality by segregating DNA damage.

This study investigates R-loop dynamics during mouse early embryonic development and shows their role in regulating transcription during the maternal-to-zygotic transition.

The paper identifies the role of Oct4 and Sox2 in establishing the pluripotency network in early mouse embryos through chromatin and transcriptome analysis.

This study shows TET3 regulates terminal differentiation by affecting mitochondrial metabolic maturation and oxidative phosphorylation in intestinal epithelial cells.

This study identifies a Sox2 mutation that enhances Sox/Oct cooperativity, improving iPSC reprogramming efficiency and enabling reprogramming of aged cells across species.

This study creates a 3D spatial transcriptome atlas of mouse embryos at embryonic day 13.5, integrating with single-cell data to reveal molecular regulation of organ development.