Hans Robert Schöler

This study identifies Pcbp1's role in enhancing amino acid metabolism during the naive-to-primed pluripotency transition, linking its deficiency to embryo growth arrest and reduced protein synthesis.

This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.

The paper identifies the role of Oct4 and Sox2 in establishing the pluripotency network in early mouse embryos through chromatin and transcriptome analysis.

This paper introduces a 3D in vitro system to model human skeletal muscle development and identifies a pool of myogenic progenitors that can resist specification and expand in vitro.

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

This study identifies a Sox2 mutation that enhances Sox/Oct cooperativity, improving iPSC reprogramming efficiency and enabling reprogramming of aged cells across species.

This paper introduces a mesh microelectrode array for non-invasive electrophysiology in neural organoids, demonstrating long-term culture and electrical activity recordings.

This study shows SARS-CoV-2 can infect and replicate in retinal organoids, affecting photoreceptor and retinal ganglion cells, and induces inflammatory gene expression.

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.