The paper investigates how cluster assembly dynamics contribute to planar cell polarity polarization by analyzing protein monomer counts in live animals and using mathematical modeling.

Nature Communications · Apr 18, 2026Peer-reviewedCell Biology

Flamingo participates in multiple models of cell competition

Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D. Axelrod

This study shows Flamingo (Fmi) is required for cell competition in Drosophila, functioning in both malignant and healthy contexts through a mechanism independent of planar cell polarity.

eLife · Dec 30, 2024Peer-reviewedDevelopmental Biology

Automated counting of Drosophila imaginal disc cell nuclei

Pablo Sanchez Bosch, Jeffrey D. Axelrod

This paper develops automated workflows for counting cell nuclei in Drosophila imaginal discs, including handling twin-spot labeled nuclei using machine learning.

Biology Open · Feb 12, 2024Peer-reviewedDevelopmental Biology

Protein phosphatase 1 regulates core PCP signaling

Song Song, Bomsoo Cho, Alexis T. Weiner, Silas Boye Nissen, Irene Ojeda Naharros, Pablo Sanchez Bosch, Kaye L. Suyama, Yanhui Hu, Li He, Tanya Svinkina, Namrata D. Udeshi, Steven A. Carr, Norbert Perrimon, Jeffrey D. Axelrod

The paper identifies Pp1-87B as a regulator of core PCP signaling by modulating Van Gogh subcellular localization and dephosphorylation in Drosophila wings.

EMBO Reports · Nov 17, 2023Peer-reviewedDevelopmental Biology