Manfred Heller

The N terminus of Alpha-1 Giardin, a parasitic annexin orthologue, is essential for oligomerization and lipid-binding activity

This study identifies the N-terminal region of 1-giardin as essential for oligomerization and lipid-binding, revealing its role in UPS and parasite virulence.

Bumped kinase inhibitor BKI-1708 interferes in cytokinesis and drives baryzoite stage conversion in the cyst-forming apicomplexan parasites Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti

This study shows that BKI-1708 induces baryzoite formation in T. gondii, N. caninum, and B. besnoiti, which exhibit distinct phenotypic and proteomic features and lack complete cytokinesis.

Stress granules formed during different RNA virus infections show remarkable plasticity and substantial virus-specific differences in their formation and composition

This study compares stress granule formation and composition during MHV and SFV infections, revealing virus-specific differences in their proteomes, kinetics, and RNA content.

Radioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis

The paper uses radioproteomics to stratify molecular response to antifibrotic treatment in pulmonary fibrosis by analyzing radiomic and proteomic profiles in mice and patients.

Ribonuclease Inhibitor and Angiogenin collaboratively regulate cell-type-specific global translation

This study identifies RNH1 and ANG as regulators of cell-type-specific global translation, showing RNH1 affects hematopoietic cells while ANG protects non-hematopoietic cells.