Christian Stald Skoven

Sex shapes capillary flows and oxygen extraction in the middle-aged mouse brain

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity

This study investigates a rodent model with an OGT-ID variant, revealing neurodevelopmental defects and behavioural abnormalities linked to O-GlcNAc dyshomeostasis.

Genetic rescue of pathogenic O-GlcNAc dyshomeostasis associated with microcephaly and motor deficits

This study investigates OGA inhibition as a potential therapy for OGT-CDG by creating a mouse model and showing partial restoration of O-GlcNAc homeostasis.

Mapping axon diameters and conduction velocity in the rat brain - different methods tell different stories of the structure-function relationship

The paper compares structure-function relationships in axons using multiple modalities, finding that different methods capture different aspects of axon diameter and conduction velocity distributions.

Anesthesia-related brain microstructure modulations detected by diffusion MRI

This study uses diffusion kurtosis MRI to show that anesthesia reduces mean diffusivity and kurtosis in both gray and white matter of mice, suggesting increased extracellular space volume.

Profiling the transcallosal response of rat motor cortex evoked by contralateral optogenetic stimulation of glutamatergic cortical neurons

The paper uses optogenetic stimulation to study transcallosal M1-M1 interactions in rats, finding a consistent negative peak response with variable amplitude and stable latency.

The effect of combined dexmedetomidine and isoflurane anaesthesia on visually evoked responses in rats -- an electrophysiological study

This study examines the effect of combined dexmedetomidine and isoflurane anaesthesia on visual evoked responses in rats, finding reduced but not fully suppressed responses in the visual cortex.