Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells
Saif Sikdar, D Kim, Tie Wang, Sacha Benaoudia, Jahanara Rajwani, Kristofor K. Ellestad, Pauline Douglas, Růžena Filandrová, Theodore B. Verhey, Katrina I Ellestad, Marija Drikic, D.R. Derksen, Ian A. Lewis, Marco Gallo, A. Sorana Morrissy, , Douglas J. Mahoney
This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.
bioRxiv · Apr 27, 2026 · PreprintCancer Biology