Author

Rachael E. Rayner

The Ohio State UniversityORCID 0000-0002-0659-559XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Estelle Cormet‐BoyakaiD· 2 shared Jacob T. StackiD· 2 shared Karen L Kanke· 2 shared Reza NouriiD· 2 shared Sriram VaidyanathaniD· 2 shared Tatyana A. VetteriD· 2 shared Aparna VenugopalaniD· 1 shared Carlos Jose SuareziD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Estelle Cormet‐BoyakaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

GeneticsMolecular Therapy — Nucleic AcidsPeer-reviewedSep 17, 2024

DNA-PKcs Inhibition Improves Sequential Gene Insertion of the Full-Length CFTR cDNA in Airway Stem Cells

Jacob T. Stack, Rachael E. Rayner, Reza Nouri…·Sriram Vaidyanathan

This study shows that inhibiting DNA repair pathways with AZD7648 improves gene insertion efficiency in airway stem cells for CFTR correction, but may introduce toxicity.

8 citations

humanCRISPR screen

𝕏 PostBluesky

Molecular BiologybioRxivPreprintFeb 1, 2024

Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Gene Insertion in Primary Cells

Karen L Kanke, Rachael E. Rayner, Eli Abel…·Sriram Vaidyanathan

The paper demonstrates that chemically modified ssDNA (eDNA) significantly improves gene insertion efficiency in primary cells compared to unmodified ssDNA, achieving therapeutic levels in clinically relevant loci.

1 citation

humanCRISPR screen

𝕏 PostBluesky