Carlos Jose Suarez

DNA-PKcs Inhibition Improves Sequential Gene Insertion of the Full-Length CFTR cDNA in Airway Stem Cells

This study shows that inhibiting DNA repair pathways with AZD7648 improves gene insertion efficiency in airway stem cells for CFTR correction, but may introduce toxicity.

A Deep Learning Model for Molecular Label Transfer that Enables Cancer Cell Identification from Histopathology Images

This paper introduces HEMnet, a deep learning model that transfers molecular labels from immunohistochemistry to H&E images to identify cancer cells without manual annotation.

Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

The paper develops a high-coverage sequencing approach to profile microsatellite and chromosomal instability in colorectal cancer, revealing co-occurrence of MSI and CIN features.

Joint single cell DNA-Seq and RNA-Seq of gastric cancer reveals subclonal signatures of genomic instability and gene expression

The paper combines single cell DNA-Seq and RNA-Seq in gastric cancer to reveal subclonal genomic instability and gene expression patterns, showing evidence of tumor evolution.

Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I

This study uses CRISPR/Cas9 to edit hematopoietic stem cells to express iduronidase, correcting Mucopolysaccharidosis type I in mice.