Modulation of calcium signaling on demand to decipher the molecular mechanisms of primary aldosteronism
Bakhta Fedlaoui, Teresa Cosentino, Zeina Reda Al Sayed, Rita Alexandre Coelho, Isabelle Giscos-Douriez, Nicolò Faedda, May Fayad, Jean‐Sébastien Hulot, Christopher J. Magnus, Scott M. Sternson, Simon Travers-Allard, Stéphanie Baron, David Pentón, Fabio Luiz Fernandes-Rosa, Maria‐Christina Zennaro, Sheerazed Boulkroun
This study establishes an adrenocortical cell model to modulate sodium entry and calcium signaling, revealing its role in aldosterone biosynthesis and PA development.
Hypertension · Feb 12, 2025Peer-reviewedPhysiology