Scott M. Sternson

Whole-Brain Co-Mapping of Gene Expression and NeuronalActivity at Cellular Resolution in Behaving Zebrafish

The paper develops WARP, a platform integrating neuronal activity and gene expression data in zebrafish brains, revealing functional roles of molecularly defined cell populations and their activity correlations.

The promise and peril of comparing fluorescence lifetime in biology revealed by simulations

This paper introduces FLiSimBA, a simulation framework to analyze fluorescence lifetime data, revealing limitations and proposing advancements in FLIM for biological applications.

Modulation of calcium signaling on demand to decipher the molecular mechanisms of primary aldosteronism

This study establishes an adrenocortical cell model to modulate sodium entry and calcium signaling, revealing its role in aldosterone biosynthesis and PA development.

Projectome-defined subtypes and modular intra-hypothalamic subnetworks of peptidergic neurons

The paper identifies 31 projectome-defined subtypes of hypothalamic neurons and six modular subnetworks, revealing the organization of axon projections and their functional roles.

Multimodal mapping of cell types and projections in the central nucleus of the amygdala

This study maps cell types and axon projections in the central nucleus of the amygdala using single-cell RNA-sequencing and spatial techniques, revealing distinct molecular and connectivity patterns.

Characterization of ultrapotent chemogenetic ligands for research applications in non-human primates

The paper characterizes two ultrapotent chemogenetic ligands in rhesus macaques, showing good brain penetrance and safety for potential neuroscience research applications.

Expansion-Assisted Iterative-FISH defines lateral hypothalamus spatio-molecular organization

The paper introduces EASI-FISH, a method for spatial gene expression profiling in thick brain sections, and applies it to discover novel subregions in the lateral hypothalamus.

Medial prefrontal cortex guides goal-directed decision-making about hunger and thirst

This study shows that the medial prefrontal cortex (mPFC) is essential for making decisions about hunger and thirst in mice, particularly when need states are variable, and that outcome evaluation is critical for accurate decision-making.

Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.