Author

Tautvydas Karvelis

Vilnius UniversityORCID 0000-0002-0685-2947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Algirdas GrybauskasiD· 1 shared Ana GvozdenoviciD· 1 shared András TálasiD· 1 shared Charles D. YehiD· 1 shared F. V. Gorbenko· 1 shared Gerald SchwankiD· 1 shared Giedrius SasnauskasiD· 1 shared Gytis DruteikaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Algirdas GrybauskasORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Directed evolution of compact RNA-guided nucleases for enhanced activity in mammalian cells

F. V. Gorbenko, Irene Sala, Young-Yoon Lee, Lilly van de Venn, Charles D. Yeh, András Tálas, Tautvydas Karvelis, Gytis Druteika, Luca V. Bechter, Iryna Vykhlyantseva, Markus Schröder, Ana Gvozdenovic, Gerald Schwank, Virginijus Šikšnys, Jacob E. Corn

The paper improves the activity of compact RNA-guided nucleases in mammalian cells through directed evolution, resulting in variants with higher editing efficiency and reduced off-target effects.

Genome biology · Jun 16, 2026Peer-reviewedBioengineering

Off-target detection of CRISPR-Cas9 nuclease in vitro with CROFT-Seq

Paulius Toliusis, Algirdas Grybauskas, Tomas Šinkūnas, Tautvydas Karvelis, Giedrius Sasnauskas, Mindaugas Zaremba

This paper introduces CROFT-Seq, a method for detecting Cas9 off-target sites in vitro, which is sensitive, rapid, and cost-effective compared to existing methods.

Synthetic Biology · Jan 1, 2026Peer-reviewedBiochemistry