Stephanie K. Bonney

Perivascular fibroblasts locally regulate the vasomotor dynamics of pial arterioles

This study identifies perivascular fibroblasts as regulators of cerebral vasomotion and cerebrospinal fluid movement through calcium dynamics and Gq signaling.

Chemogenetic Pericyte Activation Reveals Broad Contractile Ability and Limbic Vulnerability to Capillary Flow Deficits

This study uses chemogenetic activation of pericytes in mice to show their ability to contract capillaries and cause hypoperfusion, particularly in limbic regions.

Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels

The paper shows that capillary injury and regression lead to sustained vasoconstriction in upstream vessels, reducing blood flow in both injured and uninjured regions of the microvascular network.

Impaired capillary-venous drainage contributes to gliosis and demyelination in white matter during aging

The paper shows that impaired capillary-venous drainage in aging mice leads to hypoperfusion, gliosis, and demyelination in deep white matter regions.

Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature

This study tracks the origin and development of perivascular fibroblasts in postnatal mice, showing they originate from the meninges and expand via proliferation and migration to cover cerebral vasculature by P14.

Endothelial structure contributes to heterogeneity in brain capillary diameter

The paper examines how endothelial cell structure influences capillary diameter heterogeneity in mouse brain microvasculature using electron microscopy data.

Formation and function of the meninges arachnoid barrier around the developing brain

The paper identifies Wnt-β-catenin signaling repression as key to arachnoid barrier cell specification in mouse meninges and shows its role in preventing pathogen entry during development.

Public volume electron microscopy data: An essential resource to study the brain microvasculature

The paper presents a meta-analysis of electron microscopy datasets to explore cerebrovascular structures and identifies features important for vascular function and segmentation improvements.

Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging

The paper uses in vivo two-photon imaging to distinguish perivascular fibroblasts from mural cells in mouse cerebral cortex, revealing unique structural and distributional features.

A cellular atlas of the developing meninges reveals meningeal fibroblast diversity and function

This study creates a cellular atlas of developing meningeal fibroblasts in mice and humans, revealing distinct subtypes and their functional roles in CNS development.